ESNL Research Featured in Advances in Ketogenic Diet Book

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Giovanna Muscogiuri, Vinee Purohit, Richard B Kreider, Salvador Vargas, Diego A Bonilla, Iraklis I Pipinos.  Advances in Ketogenic Diet.  Scientific Research Publishing. 2019, pp. 209.


The ketogenic diet is a high-fat, adequate-protein, low-carbohydrate diet that in medicine is used primarily to treat difficult-to-control (refractory) epilepsy in children. The diet forces the body to burn fats rather than carbohydrates. Normally, the carbohydrates contained in food are converted into glucose, which is then transported around the body and is particularly important in fueling brain function. However, if little carbohydrate remains in the diet, the liver converts fat into fatty acids and ketone bodies. The ketone bodies pass into the brain and replace glucose as an energy source. An elevated level of ketone bodies in the blood, a state known as ketosis, leads to a reduction in the frequency of epileptic seizures. Around half of children and young people with epilepsy who have tried some form of this diet saw the number of seizures drop by at least half, and the effect persists even after discontinuing the diet. Some evidence indicates that adults with epilepsy may benefit from the diet, and that a less strict regimen, such as a modified Atkins diet, is similarly effective. Potential side effects may include constipation, high cholesterol, growth slowing, acidosis, and kidney stones.

Chapter 1
Treatment of glioma patients with ketogenic diets: report of two cases treated with an IRB-approved energy-restricted ketogenic diet protocol and review of the literature
Chapter 2
The management of very low-calorie ketogenic diet in obesity outpatient clinic: a practical guide
Chapter 3
Ketogenic diet in a patient with congenital hyperinsulinism: a novel approach to prevent brain damage
Chapter 4
Efficacy of ketogenic diet on body composition during resistance training in trained men: a randomized controlled trial
Chapter 5
Effects of a ketogenic diet during pregnancy on embryonic growth in the mouse
Chapter 6
Ketolytic and glycolytic enzymatic expression profiles in malignant gliomas: implication for ketogenic diet therapy
Chapter 7
Elemental changes in the hippocampal formation following two different formulas of ketogenic diet: an X-ray fluorescence microscopy study
Chapter 8
Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder
Chapter 9
Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy
Chapter 10
Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus–Merzbacher disease
Chapter 11
Effect of a four-week ketogenic diet on exercise metabolism in CrossFit-trained athletes
Chapter 12
A gestational ketogenic diet alters maternal metabolic status as well as offspring physiological growth and brain structure in the neonatal mouse
Chapter 13
Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet
Chapter 14
Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma
Chapter 15
Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia
Readership: Students, academics, teachers and other people attending or interested in Ketogenic Diet